Preparation of hydrophobic acrylic intraocular lens materials using various crosslinking agents to reduce glistening

Abstract

Glistening is the condensation of water that forms within the intraocular lens (IOL) materials. In this study, a new approach was attempted to reduce the glistening using various types and content of crosslinking agents. Hydrophobic acrylic IOL materials were prepared from 2-phenoxyethyl acrylate using three different crosslinking agents: ethylene glycol dimethacrylate (EGDMA), 1,4-butanediol diacrylate (BDDA), and glycerol 1,3-diglycerolate diacrylate (GDGDA). The IOL material cross-linked with the GDGDA showed the least amount of glistening. However, the IOL materials exhibited the largest amount of glistening when cross-linked with the EGDMA, indicating that the glistening decreased in the order of GDGDA > BDDA > EGDMA.

Graphical Abstract

Keywords:

• Crosslinking agent
• glistening
• glycerol 1,3-diglycerolate diacrylate
• intraocular lens materials
• 2-phenoxyethyl acrylate

Data availability statement

Data will be made available on request.