Summary on polyurethane-based drug delivery system in perspective for future implantable drug system

Abstract

Recent research is based on biocompatible drug delivery systems due to the need for bioavailability, route of administration, dose dumping, and first-pass metabolism. Despite its excellent mechanical strength, elasticity, and stability, polyurethane has associated risk factors such as high hydrophobic nature and long-term degradability. This review focuses on providing insight into polyurethane as a drug delivery system. The key objective of the review is to signify the importance of polyurethane in biomedical, the essential compounds to synthesize polyurethane, and the types of polyurethane. The review has highlighted polyurethane’s drug loading and release capacity and its composites in various forms. The essential biological studies such as polyurethane’s antibacterial, antiinflammatory, and anticancer activity were also discussed. Herein, polyurethane and its hybrid composites can be a potential material for future implantable drug delivery systems.

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Keywords:

• Biological studies and implantable drug delivery system
• drug delivery system
• drug loading
• drug release
• hydrophobicity
• mechanical strength
• polyurethane

Acknowledgments

The authors would like to acknowledge SRMIST for the immense support during the research period.

Conflict of interest

No potential conflict of interest was reported by the author(s).

Data availability

Not applicable.

Additional information

Notes on contributors

Neeraja Bose

Neeraja Bose is currently pursuing the PhD program from SRM institute of Science and Technology. The author has area of interest in polymer and its composite film for anticancer drug delivery therapy. The author has also published a good sum of research articles based on polyurethane film for anticancer therapy. The author’s interest also involves interdisciplinary area such as water treatment, pesticidal removal, and biosensing.

Kalaivizhi Rajappan

Kalaivizhi Rajappan is an associate professor for SRM institute of Science and Technology. The author’s area of interest is water treatment and biomedical application. The author has defended her thesis on polymer film for water treatment. She is the corresponding author for seven research scholars currently.