![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
Tissue engineering is aimed to regenerate damaged or lost tissues by exploiting polymeric scaffolds, proper cells, and growth factors. Both hard and soft tissue damages in proposed implant sites are the main issues before implant therapy. They are usually caused by trauma, infection/periodontal disease, and atrophy. Bone tissue engineering using alloplastic biomaterials and polymeric scaffolds have been shown to be able to regenerate bone defects with comparable bone density at peri-implant defect sites. In addition, natural scaffolds, collagen matrices, and polymeric matrices have been developed to regenerate soft tissue to cover implant sites. Although the results of pre-clinical studies have shown the potential of tissue engineering in the regeneration of peri-implant defects, the clinical studies are limited to make a conclusion regarding the clinical benefits of hard and soft tissue engineering in peri-implant defects.
Graphical Abstract
Hard and soft tissue damages in peri-implant defect sites are managed with tissue engineering. By using various scaffolds/biomaterials , proper cells and growth factors have been shown to be able to regenerate bone defects and regenerate soft tissue to cover implant sites. (Created with BioRender.com)
Authors’ contributions
N R and M S contributed to the design of the paper. N R, M S, N A, S AF, A Z, M H, and F S also contributed to data collection, writing the manuscript, and preparing tables and figures. The corresponding authors designed the manuscript and was also involved in the writing and revisiting of the text.
Disclosure statement
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.