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Abstract
Cephradine (Hcephra) interacts with transition metal ions to give [Fe(cephra)Cl2] and [M(cephra)Cl] complexes (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) which were characterized by physicochemical and spectroscopic methods; a tetrahedral geometry is suggested for their structures where cephradine behaves as monoanionic tridentate ligand. The complexes have been screened for antibacterial activity against several bacteria, and the results showed that all metal complexes tested had lower antibiotic activity than the free ligand.
Acknowledgements
Our sincere thanks to the Comision de Investigacion from the Universidad de Oriente for providing financial support as well as Lic. Erasto Bastardo for elemental analyses.