Abstract
New complexes of gallium(III) and thallium(I) derived from 5,6-dimethyl-1H-indol-2,3-dione hydrazinecarbothioamide (L1H) and 5,6-dimethyl-1H-indol-2,3-dione hydrazinecarboxamide (L2H) have been prepared and investigated using a combination of microanalytical analysis, melting point, molar conductance measurement, electronic, IR, 1H NMR, and 13C NMR spectral studies. Gallium isopropoxide interacts with the ligands in 1 : 1, 1 : 2, and 1 : 3 molar ratios resulting in the formation of colored products, whereas TlCl forms only unimolar products. The mono- and bis-alkoxy derivatives are dimeric, while the tris ligand metal complexes are monomeric. On the basis of conductance and spectral evidences, a pentacoordinate structure for gallium(III) 1 : 1 complexes, hexacoordinate structure for 1 : 2 and 1 : 3 complexes, and a bicoordinate geometry for thallium(I) complexes have been assigned. The ligands are coordinated to gallium(III) and thallium(I) via the azomethine nitrogen and the thiolic sulfur/enolic oxygen. The antimicrobial activities of the ligands and complexes have been screened in vitro against bacteria Pseudomonas cepacicola and Bacillus subtilis and fungi Collectatrichum capsici and Fusarium oxysporum. The complexes have higher activities than the free bases. In vivo studies of the ligands and their corresponding complexes have also been carried out to assess their antifertility and antiradiation activities. The results of these activities indicate the antiandrogenic and radiation protective nature of these complexes.