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Original Articles

DNA cleavage,in vitro antimicrobial and electrochemical studies of Co(II), Ni(II), and Cu(II) complexes withm-substituted thiosemicarbazide Schiff bases

, , , , &
Pages 688-699 | Received 12 Jul 2009, Accepted 30 Sep 2009, Published online: 16 Feb 2010
 

Abstract

Co(II), Ni(II), and Cu(II) complexes, ML2 · 2H2O have been synthesized with Schiff bases derived from m-substituted thiosemicarbazides and 2-methoxy benzaldehyde. The complexes are soluble in DMF/DMSO and non-electrolytes. From analytical, spectral (IR, UV-Vis, ESR, and FAB-mass), magnetic and thermal studies octahedral geometry is proposed for the complexes. The redox behavior of the complexes was investigated using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by Minimum Inhibitory Concentration method. DNA cleavage is studied by agarose gel electrophoresis method.

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