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Original Articles

Synthesis, characterization, and biological studies of lanthanide complexes with 2,6-pyridine dicarboxylic acid and α-picolinic acid

, , , , &
Pages 2360-2369 | Received 06 Jan 2010, Accepted 22 Apr 2010, Published online: 13 Jul 2010
 

Abstract

Four new solid ternary complexes of lanthanide with 2,6-pyridine dicarboxylic acid and α-picolinic acid [Ln(DPA)(Lα)(H2O)] · 2H2O (Ln = La3+, Ce3+, Eu3+, or Gd3+; DPA = 2,6-pyridine dicarboxylic acid; HLα = α-picolinic acid) have been synthesized and characterized by elemental analysis, molar conductance, FT-IR, UV–Vis, and TG–DTA. The antibacterial activities indicate that all the complexes exhibit antibacterial ability against Escherichia coli and Staphylococcus aureus with broad antimicrobial spectra. The anticancer activity of the La complex against K562 tumor cell in vitro is measured using methyl thiazolyl tetrazolium (MTT) colorimetry and flow cytometry. The La complex can induce K562 tumor cell apoptosis, presenting the best apoptosis effect by acting on the S period after inducing K562 tumor cell for 72 h.

Acknowledgments

We are grateful to Leading Academic Discipline Project of Shanghai Normal University (DZL806), the National Nature Science Foundation of China (20671063), Shanghai Key Discipline Construction Project (S30406), the Key Subjects of Shanghai Normal University (DZL711), and the research of Shanghai Normal University (SK200829) for the financial support.

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