Divalent metal macrocyclic complexes derived from acetonylacetone and carbohydrazide with their spectroscopic and antibacterial studies

Abstract

A series of macrocyclic complexes are synthesized by condensation of acetonylacetone and carbohydrazide in the presence of divalent metal salts in methanol. The complexes are [M(TML)X₂], where M = Co(II), Ni(II), Cu(II), and Zn(II); X = Cl⁻, , CH₃COO⁻ and TML is a tetradentate macrocyclic ligand. The complexes have been characterized by elemental analyses, conductance measurements, magnetic measurements, NMR, infrared, and electronic spectral studies. The low value of molar conductance indicates non-electrolytes. A six-coordinate geometry with trans coordination of monodentate ligands may be proposed for all the complexes. All the metal complexes were also tested for their in vitro antibacterial activities against some bacterial strains. The results obtained were compared with standard antibiotic, Ciprofloxacin. Some of the tested complexes show good antibacterial activities against some bacterial strains.

Keywords:

• Antibacterial activity
• Carbohydrazide
• Macrocyclic complexes
• MIC

Acknowledgments

D.P. Singh thanks the authorities of NIT, Kurukshetra for providing the necessary research facilities.