Synthesis, spectral characterization, and antidiabetic study of new furan-based vanadium(IV) complexes

Abstract

We have synthesized furan-based vanadium complexes, bis(5-nitrofuran-2-carboxylato)oxovanadium(IV) – [VO(5NF)₂], bis(1-furan-2-yl-ethanonato)oxovanadium(IV) sulfate – [VO(2AF)₂]SO₄, and bis(5-methyl-2-furalato)oxovanadium(IV) sulfate – [VO(MFFA)₂]SO₄ possessing [VO(O₄)] coordination mode. These complexes are characterized by physico-chemical and spectroscopic methods. Based on electron paramagnetic resonance parameters, the proposed geometry is close to a distorted square pyramid. Animal study was carried out using standard protocol and the complete profile of glucose, protein, and total cholesterol levels were analyzed followed by an oral glucose tolerance test.

Keywords:

• Furan-like ligands
• EPR
• Oral glucose tolerance test

Acknowledgments

The authors thank the Management of VIT for their continuous support and encouragement. The work was supported by a Research Grant provided by CSIR, India. Thanks are also due to SAIF, IITM Chennai for mass and EPR studies and Technology Business Incubator, VIT University for providing analytical facilities.