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Journal of Coordination Chemistry Volume 64, 2011 - Issue 4
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Original Articles

Synthesis, molecular docking, and activity of Schiff-base copper(II) complex with N-n-butylsalicylaldiminate as Helicobacter pylori urease inhibitor

Yong Ming Cui Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, P.R. China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.R. China
,
Yuguang Li Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, P.R. China
,
Ying Jie Cai Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, P.R. China
,
Wu Chen Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, P.R. China
&
Hai Liang Zhu Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, P.R. China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.R. ChinaCorrespondence[email protected]
Pages 610-616 | Received 09 Oct 2010, Accepted 22 Nov 2010, Published online: 28 Jan 2011
 
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Abstract

A Schiff-base copper(II) complex, bis(N-n-butylsalicylaldiminato)copper(II), was synthesized and its solid-state structure was determined by X-ray crystallography. Its inhibitory activity against Helicobacter pylori urease was evaluated in vitro and it showed strong inhibitory activity against urease (IC50 = 0.95 µM), compared with acetohydroxamic acid (IC50 = 42.47 µM) as a positive reference. A docking analysis using the AUTODOCK 4.0 program was performed to explain the potent inhibitory activity of the complex against urease.

Acknowledgments

This study was financed by grant from National Natural Science Foundation of China (50978208), Hubei National Science Foundation (2009CDA022), and Education Office of Hubei Province (D20091704 and Q20101610).

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