Abstract
Two new nickel complexes, [Ni(L1)2] · 2(CH3OH) (1) and [Ni(L2)2] · 2(CH3OH) (2), where HL1 is 4-chloro-2-((2-hydroxy-ethylimino)methyl)phenol and HL2 is 4-fluoro-2-((2-hydroxy-ethylimino)methyl)phenol, have been synthesized and characterized by single-crystal X-ray diffraction and UV-Vis absorption spectra. The coordination polyhedron of nickel(II) in each complex can be described as distorted octahedral. The interactions between the complexes and calf thymus (CT)-DNA/DNA were investigated by UV-Vis spectra and agarose gel electrophoresis. The results show that the complex transforms supercoiled to nicked form and exhibits effective DNA cleavage activity via hydrolytic cleavage mechanism.
Acknowledgments
We are grateful for the financial support from the National Nature Science Foundation of China (20971102, 20871097) and the Foundation of the Excellent Middle-Young Innovation Group of Education Department of Hubei province (T200802), China.