Synthesis, spectral analysis, and molecular modeling of bioactive Sn(II)-complexes with oxadiazole Schiff bases

Abstract

Sn(II)-complexes of seven 2-amino-5-substituted-aryl-1,3,4-oxadiazole Schiff bases have been synthesized and characterized by various physico-chemical studies. Their structures have been confirmed by elemental analyses, infrared, ¹H NMR, UV-Vis, and mass spectral studies as well as thermal decomposition. Conductance measurements in methanol show these complexes to be non-electrolytes, and the molecular weight determinations support the proposed molecular formulae. The molecular structures of the complexes have been optimized by CS Chem 3-D Ultra Molecular Modeling and Analysis Program showing tetrahedral geometry. The bio-efficacy of the complexes has been examined against the growth of bacteria (Escherichia coli and Staphylococcus aureus) and fungi (Aspergillus flavus and Candida albicans) in vitro to evaluate their anti-microbial potential.

Keywords:

• Sn(II)-complexes
• Oxadiazole Schiff bases
• Molecular modeling
• Antimicrobial activity

Acknowledgments

The authors are grateful to Dr Mohamed El-Zarie (Gakushuin University, Japan) for assistance in measuring ¹H NMR and mass spectra carried out in this work.