Advanced search
Publication Cover
Journal of Coordination Chemistry Volume 64, 2011 - Issue 22
Submit an article Journal homepage
177
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Mixed-ligand manganese(II)-phenolate complexes: study of DNA cleavage, cytotoxic activity, and induction of apoptosis

En-Jun Gao Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, ChinaCorrespondence[email protected]
,
Ying Zhang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lin Lin Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Ren-Shu Wang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lei Dai Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Qi Liang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Ming-Chang Zhu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Mei-Lin Wang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lei Liu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Wen-Xuan He Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
&
Yan-Jin Zhang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
 show all
Pages 3992-4005 | Received 21 Aug 2011, Accepted 14 Oct 2011, Published online: 11 Nov 2011
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)2(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.

Acknowledgements

We gratefully acknowledge the Natural Science Foundation of China (No. 20971090, 21171118), the science and technology projects fund of Shenyang City (No. F10-215-1-00).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,057.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.