Abstract
Two Schiff-base copper(II) complexes, bis(N-n-butyl-5-chlorosalicylaldiminato) copper(II) (1) and bis(N-n-butyl-4-methoxysalicylaldiminato) copper(II) (2), were synthesized and their solid-state structures were determined by X-ray crystallography. Complex 1 displays a distorted square-planar geometry, while 2 possesses square-planar geometry. Copper(II) complexes 1 and 2 showed strong inhibitory activity against jack bean urease (IC50 = 2.7, 3.5 µmol L−1), compared with acetohydroxamic acid (IC50 = 63.00 µmol L−1). A molecular modeling study was carried out via the DOCK program to gain understanding of the potent inhibitory activity of these copper species against jack bean urease.
Acknowledgments
This work was financially supported by China Postdoctoral Science Foundation (20100481108), Natural Science Foundation of Hubei Province (2009CDA022), and the Education Office of Hubei Province (D20091704, Q20101610).