Synthesis, spectroscopic properties, and antimicrobial activity of some new 5-phenylazo-6-aminouracil-vanadyl complexes

Abstract

Six complexes, [VO(L¹-H)₂] · 5H₂O (1), [VO(OH)(L^2,3−H)(H₂O)] · H₂O (2,3), [VO(OH)(L^4,5−H)(H₂O)] · H₂O (4,5), [VO(OH)(L⁶−H)(H₂O)] · H₂O (6), were prepared by reacting different derivatives of 5-phenylazo-6-aminouracil ligands with VOSO₄ · 5H₂O. The infrared and ¹H NMR spectra of the complexes have been assigned. Thermogravimetric analyses (TG, DTG) were also carried out. The data agree quite well with the proposed structures and show that the complexes were finally decomposed to the corresponding divanadium pentoxide. The ligands and their vanadyl complexes were screened for antimicrobial activities by the agar-well diffusion technique using DMSO as solvent. The minimum inhibitory concentration (MIC) values for 1–4 and 6 were calculated at 30°C for 24–48 h. The activity data show that the complexes are more potent antimicrobials than the parent ligands.

Keywords:

• 5-Phenylazo-6-aminouracils-VO²⁺ complexes
• IR
• Thermal analysis
• ¹H NMR
• Antimicrobial activity

Acknowledgments

The authors are very grateful to Zagazig University Research Fund for providing financial support (project no. 36K12/M3).