Transition metal complexes of 3-acetylpyridine ⁴N-(2-pyridyl)thiosemicarbazone (HAPS); structural, spectroscopic, and biological studies

Abstract

This work examines transition metal ion complexes which have been synthesized from 3-acetylpyridine ⁴ N-(2-pyridyl)thiosemicarbazone (HAPS) (1). [Cu(HAPS)₂Cl₂] · H₂O (2), [Hg(HAPS)₂Cl₂] (3), [Ni(HAPS)Cl₂] · 2H₂O (4), [UO₂(APS)₂] · 2H₂O (5), [VO(HAPS)₂]SO₄ · H₂O (6), and [Zn(HAPS)₂Cl₂] (7) were characterized by elemental analysis, spectral (IR, ¹H-NMR, and UV-Vis), magnetic, and molar conductance measurements. The biochemical studies showed that 2 and 3 have powerful and complete degradation on both DNA and protein. Complexes 2, 4, and 7 showed significant antioxidant properties, especially scavenging on superoxide and hydroxyl radicals. The antibacterial screening demonstrated that all studied complexes have maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.

Keywords:

• 3-Acetylpyridine
• Thiosemicarbazone complexes
• Spectroscopy
• Antioxidant
• Antibacterial

Acknowledgments

The financial support by the Deanship of Scientific Research (Project Number 110013) King Faisal University, Saudi Arabia, is gratefully acknowledged. The author thanks Dr Magdy Youssef for helping with the biological part.