New supramolecular ferrocenyl amides: synthesis, characterization, and preliminary DNA-binding studies

Abstract

Three ferrocenyl amides have been synthesized and characterized by analytical techniques. Based on single-crystal X-ray analysis, a supramolecular structure was attributed to 1 owing to the presence of intermolecular non-covalent interactions. UV-Visible spectroscopy, viscometry, and dynamic laser light scattering was used to assess the mode of interaction and binding of these complexes with DNA, which varied in the sequence 1 > 2 > 3. The binding is presumably due to the ability of these complexes to form secondary non-covalent interactions with DNA bases. Complex-DNA adduct formation depends on the nature of R of the amide.

Keywords:

• Ferrocenyl amide
• DNA-binding
• Non-covalent interaction

Acknowledgments

We are grateful to Higher Education Commission and Quaid-i-Azam University, Islamabad, Pakistan for financial support.

Notes

These two authors contributed equally.

These two authors contributed equally.

Additional information

Notes on contributors

Fatima Javed

These two authors contributed equally.

Ataf Ali Altaf

These two authors contributed equally.