Synthesis, characterization, and antibacterial activities of two new copper(II) glycinate complexes incorporating 2-(4′-thiazolyl)benzimidazole/2-(2-pyridyl)benzimidazole

Abstract

Two new complexes, [Cu(TBZ)(Gly)(H₂O)]Cl (1) and [Cu(HPB)(Gly)Cl] · 2H₂O (2) (TBZ = 2-(4′-thiazolyl)benzimidazole, HPB = 2-(2-pyridyl)benzimidazole, and Gly = glycinate), have been synthesized and characterized by elemental analysis, molar conductivity, UV-Vis, and IR methods. The complexes, structurally characterized by single-crystal X-ray crystallography, show a slightly distorted square-pyramidal coordination geometry in which two nitrogen atoms of TBZ or HPB and the carboxylate oxygen and amino nitrogen of glycinate bind in the plane and a water or chloride coordinated at the axial site. The complexes, free ligands, and copper(II) chloride were tested for their ability to inhibit growth of Bacillus subtilis, Staphylococcus aureus, and Salmonella. The results show that the complexes have good antibacterial activities against the microorganisms compared with their ligands and copper(II) chloride.

Keywords:

• Copper(II) complexes
• 2-(4′-Thiazolyl)benzimidazole
• 2-(2-Pyridyl)benzimidazole
• Glycinate
• Antibacterial activity

Acknowledgments

We acknowledge the financial support of the 211 Project Program Foundation of South China Agricultural University (2009B010100001) and the Program of Guangdong Provincial Science & Technology (2009B020312010).