Synthesis, characterization, and cytotoxicity of complexes of palladium(II) with 1,4-diaminobutane/1,3-diaminopropane and 4-toluenesulfonyl-L-amino acid dianion

Abstract

Eight new palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and 1,4-dab/1,3-dap, [Pd(1,4-dab)(TsglyNO)] · H₂O (1), [Pd(1,4-dab)(TsvalNO)] (2), [Pd(1,4-dab)(TsleuNO)] (3), [Pd(1,4-dab)(TsileNO)] (4), [Pd(1,4-dab)(TsserNO)] · 0.5H₂O (5), [Pd(1,4-dab)(TspheNO)] · 0.5H₂O (6), [Pd(1,4-dab)(TsthrNO)] · H₂O (7), and [Pd(1,3-dap)(TsserNO)] (8), have been synthesized and characterized by elemental analysis, IR, UV, ¹H NMR, and mass spectrometry. Crystal structure of 8 has been determined by X-ray diffraction. The cytotoxicities were tested by MTT assay. The results indicate the complexes exert cytotoxic effects against HL-60 and Bel-7402. The structure–activity relationship suggests that both amino acids and N-containing ligands have important effects on cytotoxicity, but the IC₅₀ values do not show definite correlation with variation of these ligands.

Keywords:

• Palladium(II) complexes
• 4-toluenesulfonyl-L-amino acid dianion
• 1,4-Diaminobutane/1,3-Diaminopropane
• Cytotoxicity

Acknowledgments

This work was supported by the Special Foundation for State Major New Drug Research Program of China (Grant No. 2009ZX09103-139), the National Basic Research 973 Program (Grant No. 2010CB534913), Hebei Province Nature Science Fund for Distinguished Young Scholars (Grant No. B2011201164), the Nature Science Fund of Hebei Province (Grant No. B2011201135), the Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province (Grant No. 11966412D, 12966418D), and the Key Research Project Foundation of Department of Education of Hebei Province (Grant No. ZD2010142).