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Abstract
Three new quinolone drug molecules modifying Keggin polyoxometalate compounds have been synthesized under hydrothermal conditions and structurally characterized. Single-crystal X-ray diffraction analysis shows that Keggin clusters modified by [Cu2(Enro)3H2O]4+ subunits result in formation of dimer {[Cu2(Enro)3H2O][SiW12O40]}2 in 1; in 2, Keggin clusters are modified by two [Cu(Norf)2]2+ subunits in the symmetrical coordinated mode, and then, discrete [Cu2(Norf)4][SiW12O40] is obtained; in 3, Keggin clusters are fused together via [Ni(Enro)2]2+ subunits giving the 1D drug-polyoxometalates (POMs) hybrid chain. Antitumor activities in vitro show that 3 exhibits good antitumor activity, while 1 and 2 and their parent SiW12 show no anti-SGC7901 or anti-SMMC7721 activities, indicating that the antitumor activities rest on differences of metal ions, differently affecting electron transfer between quinolone and POMs.
Acknowledgements
This study is financially supported by the National Natural Science Foundation (Grant No. 21271089), the Scientific and technological innovation team (2012TD010) and Postdoctoral Foundation in Heilongjiang Province.