Abstract
Four transition metal complexes with Schiff base and 1,10-phenanthroline, [Cu(L)(phen)]2·C2H5OH (1), [Zn(L)(phen)]2·C2H5OH (2), [Ni(L)(phen)]2·C2H5OH (3), and [Co(L)(phen)]2·C2H5OH (4) (H2L = 1-((2-hydroxynaphthalen-1-yl)methylene)thiosemicarbazide; phen = 1,10-phenanthroline) were synthesized and characterized by physico-chemical methods. The crystal structure of 1 was determined by X-ray single-crystal diffraction analysis. 1 crystallizes in the orthorhombic space group Pbca with a = 15.008(9), b = 16.100(10), c = 37.54(2) Å, V = 9070(10) Å3, Z = 8, GOOF = 1.002, R 1 = 0.0626, and wR 2 = 0.0912. The fluorescence and urease inhibitory activities of the compounds were tested. The enzymatic activity study indicated that 3 possessed potent inhibition against jack bean urease, with IC50 = 1.2 ± 0.1 μM, and about 35 times more than 42.1 ± 0.4 acetohydroxamic acid as positive reference. This suggests that inhibitory efficiency of these complexes can be strongly influenced by different transition metal ions.
Acknowledgements
This work was financially supported by the NSF of China (21001071, 21271125, 21201116), Foundation for University Key Teacher by Henan Educational Committee (2010GGJS-157), Research Program of Foundation and Advanced Technology of Henan Province (122300410386, 122102210255, 132309410397) and NSF of Henan Educational Committee (2010A150018).