Synthesis, crystal structure, and biological activities of a Zn(II) complex with a Se substituted Schiff base

Abstract

A Zn(II) complex with an organoselenium substituted Schiff base, bis{2-[(benzylimino)methyl]-4,6-dihydroselenophenol}Zn(II), has been synthesized and characterized by elemental analyses and X-ray diffraction. Zn(II) is four-coordinated by two phenolate O and two imine N from two organoselenium substituted Schiff-base ligands, forming a distorted tetrahedral geometry. The title complex and its ligand were tested in vitro for their antibacterial and antitumor activity with the complex showing higher antibacterial and antitumor activities.

Keywords:

• Organoselenium
• Schiff base
• Zn complex
• Crystal structure
• Antibacterial
• Antitumor

Acknowledgements

This work was supported by National Natural Science Foundation of China (Grant No. 21102182), Research Fund of young scholars for the Doctoral Program of Higher Education of China (Grant No. 20110096120008) and Natural Science Foundation of Jiangsu Province (Grant No. BK2012760).