Crystal structure, interaction with DNA, and bovine serum albumin of the cobalt(II) complex of demethylcantharate and 2,2′-bipyridine

Abstract

A new cobalt(II) complex [Co(DCA)(bipy)(H₂O)] (DCA = demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C₈H₈O₅; bipy = 2,2′-bipyridine, C₁₀H₈N₂) was synthesized from cobalt acetate, demethylcantharidin, and bipy. This complex was characterized by elemental analysis, molar conductance, infrared spectra, and X-ray single-crystal diffraction. It crystallized in orthorhombic crystal system and Pbca space group. The DNA binding of the complex was investigated by electronic absorption spectra and viscosity measurements. The complex binds to DNA via partial intercalation with binding constant K _b of 4.02 × 10⁴ L M⁻¹. The complex could quench the intrinsic fluorescence of bovine serum albumin through static quenching. The binding constant K _A was 7.28 × 10⁶ L M⁻¹ and binding site was one.

Keywords:

• Crystal structure
• Demethylcantharate
• Cobalt(II) complex
• DNA binding
• Interaction with BSA

Acknowledgment

Financial support from Natural Science Foundation of Zhejiang Province, China (Grant No. Y407301) is gratefully acknowledged.