Synthesis, crystal structure, and biological activity of a nickel(II) complex constructed by 2-phenyl-4-selenazole carboxylic acid and 1,10-phenanthroline

Abstract

A nickel(II) complex, [NiL(phen)₂]L·5H₂O (HL = 2-phenyl-4-selenazole carboxylic acid, C₁₀H₇O₂NSe, phen = 1,10-phenanthroline), was synthesized and characterized by elemental analysis and IR. The single crystal structure was determined by single-crystal X-ray diffraction. C₈₈H₇₈N₁₂Ni₂O₁₉Se₄ crystallized in the triclinic system, space group Pī. The interaction between the complex and the calf thymus DNA was studied by an ethidium bromide fluorescent probe. The antibacterial activities of the complex and ligand against five species of bacteria, Escherichia coli, Staphylococcus epidermidis, Streptococcus viridans, Staphylococcus aureus and Acinetobacter baumanii, were tested. The anticancer activities of the complex against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied by employing an MTT assay.

Keywords:

• Nickel(II) complex
• 2-Phenyl-4-selenazole carboxylic acid
• Biological activity
• Crystal structure
• 1, 10-Phenanthroline

Supplementary material

CCDC No. 803434 of the complex contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from the Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/conts/retrieving.html (or from the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: [phone]; E-mail: [email protected]).

Acknowledgment

This work was financially supported by the Natural Science Foundation of Zhejiang Province (Y4080256).