A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine and its yttrium(III) complex: synthesis, crystal structure, DNA-binding properties, and antioxidant activities

Abstract

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H₂L) and its yttrium(III) (Y(III))complex, Y₂L₂(NO₃)₂·2H₂O, have been synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Y(III) complex has been determined by single-crystal X-ray diffraction, revealing a centrosymmetric binuclear neutral entity where Y(III) centers are bridged by two phenoxo oxygens. The DNA-binding properties of the Schiff base H₂L and the Y(III) complex were investigated by spectrophotometric methods and viscosity measurements. The results suggest that ligand H₂L and Y(III) complex both bind to DNA via groove binding, and the Y(III) complex binds to DNA more strongly than H₂L. The antioxidant activity of the Y(III) complex was determined by superoxide and hydroxyl radical-scavenging method in vitro, which indicates that Y(III) complex scavenges OH· and O₂^−· radicals.

Keywords:

• Bis(N-salicylidene)-3-oxapentane-1
• 5-diamine
• Yttrium(III) complex
• Crystal structure
• DNA-binding property
• Antioxidant activities

Supplementary material

Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Center with reference number CCDC 917806. Copies of the data can be obtained, free of charge, on application to the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK. Tel: [phone]; Fax: [phone]; E-mail: [email protected] or http://www.ccdc.cam.ac.uk.

Acknowledgments

The authors acknowledge the financial support and grant from ‘Qing Lan’ Talent Engineering Funds by Lanzhou Jiaotong University. This work is also supported by the Fundamental Research Funds for the Gansu Province Universities (212086).