Synthesis, crystal structures, and cytotoxicity of 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone and its zinc(II) and diorganotin(IV) complexes

Abstract

[Zn(L)₂] (1) and [(Ph)₂Sn(L)(CH₃COO)] (2), where HL = 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone, have been synthesized and characterized. The complexes show different coordination depending on their coordinating preferences. Biological studies carried out in vitro against human leukemia K562 cells show that the diorgantin(IV) complex, 2, has significant cytotoxicity with IC₅₀ = 3.3 ± 0.5 μM.

Keywords:

• Thiosemicarbazone
• Crystal structure
• Cytotoxicity

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (21071043) and the Natural Science Foundation of Henan Province (132300410146).