Construction and properties of drug molecules modifying octamolybdate hybrid compounds

Abstract

By introducing antibacterial drug pipemidic acid into octamolybdates, two new compounds, (HPPA)₄[Mo₈O₂₆] 2H₂O (1) and [Ni₂(PPA)₂(H₂O)₄] [Mo₈O₂₆] 3H₂O (2) (PPA = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid), have been synthesized and characterized by physical methods. Single-crystal X-ray analysis reveal that 1 and 2 crystallize in the triclinic system, space group P-1, in which supramolecular interactions play vital roles in stabilizing the structure of 1 and 2. The results of their antitumor activities in vitro show that the compounds exhibit good anti-SGC7901 and anti-SMMC7721 activities, which indicates that the antitumor activities of Polyoxometalates can be modulated by the surface modification with drugs.

Keywords:

• Polyoxometalates
• Octamolybdates
• Quinolone antibacterial drugs
• Antitumor activity

Acknowledgments

This work was financially supported by the the training program for New Century Excellent Talents in universities (1253-NCET-022) in Heilongjiang Province.