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Journal of Coordination Chemistry Volume 67, 2014 - Issue 3
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Original Articles

Calixplatin: novel potential anticancer agent based on the platinum complex with functionalized calixarene

Fazel Nasuhi PurFaculty of Science, Department of Chemistry, Urmia University, Urmia, Iran;Health Technology Incubator Center, Urmia University of Medical Science, Urmia, IranCorrespondence[email protected]
&
Karim Akbari DilmaghaniFaculty of Science, Department of Chemistry, Urmia University, Urmia, IranCorrespondence[email protected]
Pages 440-448 | Received 29 Sep 2013, Accepted 10 Jan 2014, Published online: 05 Mar 2014
 
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Abstract

A functionalized calixarene with four platinum(II) centers was synthesized as a potential anticancer agent. The colorimetric cytotoxicity tests showed that it has amplified activity with respect to carboplatin against three different human carcinoma (non-small-cell lung, hepatocellular, and breast cancer) cell lines. It was most cytotoxic against the lung cancer cell line (IC50 = 2.6 μM).

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