Synthesis, characterization, and biological activities of macrocyclic polyamine complexes

Abstract

Two new dinuclear macrocyclic complexes, [Ni₂L¹(OAc)]·ClO₄ (1) and [Co₂L²(OAc)]·1.5(ClO₄)·0.5Na·2(CH₃OH) (2) (where H₂L¹ and H₂L² are the condensation products of N,N-bis(3-aminopropyl)-4-methoxybenzylamine with 2,6-diformyl-4-brominephenol and 2,6-diformyl-4-methylphenol in the presence of metal ions, respectively) have been synthesized and characterized by infrared spectra, elemental analysis, electrospray mass spectra, and X-ray single crystal diffraction. The interactions of the complexes with CT-DNA have been measured by UV-absorption titrations and fluorescence quenching experiments.

Graphical Abstract

Two new dinuclear macrocyclic polyamine complexes have been synthesized and characterized by infrared spectra, elemental analysis, ES-MS spectrum, and X-ray single crystal diffraction. The interactions of the complexes with CT-DNA have been measured by spectroscopy, viscosity, electrochemical measurements, and the agarose gel electrophoresis.

Keywords:

• Polyamine
• Macrocyclic dinuclear complex
• Binding mode
• DNA cleavage

Funding

We are thankful for the financial support from the National Nature Science Foundation of China [grant numbers 21301131, 51374158]; the Nature Science Foundation of Hubei Province [grant number 2013CFB313]; the open fund of Engineering Research Center of Nano-Geo Materials of Ministry of Education China University of Geosciences, Wuhan [grant number CUGNGM201311]; and the scientific research fund of Wuhan Institute of Technology [grant number 10122013].