New chelating agents for Cu(II), Fe(III), Al(III), and Zn(II) based on β-diketonate-3-substituted phthalide (isobenzofuranone) and isoindolinone

Abstract

The complexing capability of β-diketone-3-substituted phthalides (isobenzofuranone) or isoindolinones toward Cu(II), Fe(III), Al(III), and Zn(II) salts has been highlighted by UV–vis spectroscopic studies. Conversely, heterocyclic analogs substituted with dimethyl malonate showed no complexing ability. Further insights have been given by the determination of equilibrium constants and distribution diagram, while the synthesis, isolation, and characterization of Cu(II)-β-diketonate-isoindolinone complex has been achieved via a convenient modification of standard procedures. Moreover, in silico evaluation of bioavailability of the ligands is also discussed for potential pharmacological applications.

Graphical Abstract

Keywords:

• β-diketonate
• Metal complexes
• Heterocycles

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Correction

Acknowledgement

MIUR and University of Salerno for their financial support.