Synthesis, crystal structure, and antifungal activity of a newly synthesized polymeric mixed ligand complex of Zn(II) with 1,1-dithiolate and nitrogen donors

Abstract

A new mixed ligand complex of Zn(II) with 1,1-dicyanoethylene-2,2-dithiolate [i-MNT²⁻ = {S₂C:C(CN)₂}²⁻] and 1,3-diaminopropane as ligands has been synthesized and characterized on the basis of spectroscopy and single-crystal X-ray diffraction analysis. Spectroscopic studies and single-crystal X-ray diffraction analysis reveal that the zinc(II) complex is tetrahedral and adopts a 1,3-diaminopropane-assisted linear polymeric assembly. The molar conductance data of the complex in DMF solution show non-electrolytic nature. Biological screening effects of the complex in vitro have been tested against five fungi Synchitrium endobioticum, Pyricularia oryzae, Helminthosporium oryzae, Candida albicans (ATCC10231), and Trichophyton mentagrophytes by the disk diffusion method. A comparative study of inhibition zone values of the primary ligand K₂i-MNT·H₂O and its synthesized complex indicates that the complex exhibits a fungistatic antifungal activity whereas K₂i-MNT·H₂O does not affect P. oryzae.

Graphical Abstract

Complex of Zn(II) with 1,1-dicyanoethylene-2,2-dithiolate [i-MNT²⁻ = {S₂C:C(CN)₂}²⁻] and 1,3-diaminopropane.

Keywords:

• Mixed ligand complex
• 1,1-Dithiolate
• Nitrogen donor
• Zn(II), X-ray diffraction
• Antifungal activity

Acknowledgments

The corresponding author, Dr Arijit Das (Principal Investigator, SERB, DST Project, New Delhi), Department of Chemistry, Ramthakur College, Agartala, Tripura, India is grateful to SERB, DST, Govt. of India, New Delhi for their financial assistance (Sanction no – SERB/F/5537/2013-14 dated 27/11/2013 and D.O. No. SB/EMEQ – 014/2013). The author is also grateful to the Head, RSIC, NEHU, Shillong for microanalysis and IIT, Guwahati for doing NMR spectroscopy.