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Abstract
Four mixed-ligand complexes, [Cu3(cpa)6(pda)1] (1) (cpa = 4-chlorophenylacetic acid, pda = 1,2-diaminopropane), [Cu3(fpa)6(tn)1] (2) (fpa = 4-fluorophenylacetic acid, tn = 1,3-diaminopropane), [Cu3(cpa)6(en)1] (3) (cpa = 4-chlorophenylacetic acid, en = ethylenediamine), and [Cu3(fpa)6(pda)1] (4) (fpa = 4-fluorophenylacetic acid, pda = 1,2-diaminopropane), were synthesized by reacting 4-chlorophenylacetic acid or 4-fluorophenylacetic acid, the diamines, and metal salts. Their structures were determined by elemental analysis and single-crystal X-ray diffraction analysis. The antimicrobial activities for the metal complexes were evaluated against Escherichia coli, Pseudomonas putida, Bacillus subtilis, and Bacillus cereus. The antimicrobial results indicated that the four synthesized complexes displayed good inhibitory activity against E. coli and B. subtilis, and could be promising antibacterial agents.
Graphical Abstract
Four copper(II) complexes were synthesized and their structures were determined by elemental analysis and single crystal X-ray diffraction analysis. Some of them show good antibacterial activity.
Acknowledgements
This work was supported by Natural Science Foundation of Jiangsu Province [grant number BK20130554] and National Science & Technology Pillar Program during the Twelfth Five-year Plan Period [grant number 2012BAD36B01].