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Journal of Coordination Chemistry Volume 68, 2015 - Issue 6
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Original Articles

Synthesis, characterization, equilibria and biological activity of dimethyltin(IV) complex with 1,4-piperazine

Mohamed R. ShehataFaculty of Science, Department of Chemistry, University of Cairo, Cairo, A.R. Egypt
,
Mahmoud M.A. MohamedFaculty of Science, Department of Chemistry, University of Cairo, Cairo, A.R. Egypt
,
Mohamed M. ShoukryFaculty of Science, Department of Chemistry, University of Cairo, Cairo, A.R. Egypt;Faculty of Science, Department of Chemistry, Islamic University, Madinah, Kingdom of Saudi ArabiaCorrespondence[email protected]
,
Mohamed A. HusseinFaculty of Pharmacy, Department of Biochemistry, October 6th University, Cairo, A.R. Egypt
&
Fatma M. HusseinFaculty of Science, Department of Chemistry, University of Cairo, Cairo, A.R. Egypt
Pages 1101-1114 | Received 28 Dec 2013, Accepted 30 Dec 2014, Published online: 05 Feb 2015
 
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Abstract

The interaction of dimethyltin(IV) dichloride (DMT) with 1,4-piperazine (PIP) was investigated. The complex formation equilibria of the complexes formed in solution were investigated. The stoichiometry and stability constants of the complexes formed in solution phase were determined at different temperatures and in solutions of dioxane–water mixtures of different dielectric constants. The equilibrium constant for the displacement of piperazine coordinated to dimethyltin(IV) by inosine as a representative of DNA was calculated. (DMT)(PIP)·3H2O was synthesized and characterized by elemental analysis, spectral, and thermal techniques. The antitumor activity of the complex was screened.

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