Synthesis, crystal structure, and interaction with DNA and BSA of a chromium(III) complex with naph-gly Schiff base and 1,10-phenanthroline

Abstract

A new chromium(III) complex, [CrCl(naph-gly)phen]⋅H₂O (naph-gly = Schiff base derived from 2-hydroxy-1-naphthaldehyde and glycine, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, electrospray ionization mass spectroscopy, FT-IR, and X-ray single-crystal diffraction. The chromium(III) complex belongs to the trigonal crystal system, P3(1) space group with crystallographic data: a = b = 1.97017(16) nm, c = 1.02991(7) nm, α = β = 90°, γ =120°, V = 3.4621(5) nm³, D_c = 1.476 g⋅cm⁻³, Z = 6, F(0 0 0) = 1578, R₁ = 0.0508, wR₂ = 0.0907. There are two independent molecules in the crystallographic asymmetric unit of the chromium(III) complex. Each Cr^III is six-coordinate to form an octahedral geometry. In the crystal, a 3-D structure is formed through intermolecular hydrogen bonds. The calf thymus DNA (CT-DNA)- and bovine serum albumin (BSA)-binding properties of the complex have been studied by UV absorption, fluorescence, and circular dichroism (CD) spectroscopy. Results indicate that the chromium(III) complex binds to CT-DNA in an intercalative mode, and it can bind to BSA and cause conformational changes of BSA.

A new chromium(III) complex, [CrCl(naph-gly)phen]⋅H₂O, with a Schiff base derived from 2-hydroxy-1-naphthaldehyde and glycine and with 1,10-phenanthroline as a co-ligand has been synthesized and characterized by IR and single-crystal X-ray diffraction. The interactions of the complex with DNA and BSA have been investigated by UV absorption, fluorescence, and CD spectra.

Keywords:

• Chromium(III) complex
• Glycine
• Schiff base
• DNA
• BSA

Additional information

Funding

This project was supported by the Undergraduate Scientific-Technological Innovation and Culture Innovation Foundation of Liaocheng University [grant number SF2013126] and the Natural Science Foundation of Shandong Province of China [grant number Y2004B02].