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Journal of Coordination Chemistry Volume 68, 2015 - Issue 9
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Articles

Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents

Chengxi WangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaView further author information
,
Qiong WuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaView further author information
,
Yongchang ZengShenzhen Institute of Gerontology, Second Clinical Medical College of Jinan University, Shenzhen, ChinaView further author information
,
Dongwei HuangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaView further author information
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Chuqin YuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaView further author information
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Xicheng WangThe First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, ChinaCorrespondence[email protected]
View further author information
&
Wenjie MeiSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaCorrespondence[email protected]
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Pages 1489-1499 | Received 14 Oct 2014, Accepted 29 Jan 2015, Published online: 13 Mar 2015
 
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Abstract

Three Ru complexes coordinated by oxfloxacin, [Ru(L)2(OFX)]Cl·2H2O (L = bpy, 1; dmbpy, 2; phen, 3; and OFX = ofloxacin), were synthesized and characterized. These complexes can inhibit the growth of cervical cancer HeLa cells efficiently. Furthermore, these three complexes exhibited excellent binding affinities with DNA, as confirmed by spectroscopy methods and viscosity experiments. Therefore, the synthesized Ru(II) complexes have excellent DNA-binding abilities with potential applications in cancer chemotherapy.

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Funding

This work was supported by the Science and Technology Item Foundation of Guangzhou [grant number 2013J4100072]; the Joint Natural Sciences Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University [grant number GYFYLH201309].

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