Review: Recent advances in the investigations of NO activation on cobalt and manganese porphyrins: a brief review

Abstract

Cobalt and manganese porphyrins are known for their ability to activate small molecules. This is particularly important in the case of nitric oxide, whose role and mechanism of action in the redox biological systems have not yet been fully recognized. The goal of this article is to draw attention to some of the current trends of research in this area. The interactions involving NO itself and the primary products of its oxidation (nitrite) and reduction (nitroxyl) have been distinguished and separately discussed. The diversity of undertaken issues sheds light on both the expected behavior in biologically relevant systems as well as potential practical applications.

Graphical abstract

The results of recent research on interactions between cobalt and manganese porphyrins with nitric oxide species are summarized. The systems containing NO itself as well as its oxidized (nitrite) and reduced (nitroxyl) forms are discussed separately. Selected publications are primarily focused on the reaction mechanisms with respect to both biological systems and potential applications.

Keywords:

• Cobalt porphyrins
• Manganese porphyrins
• Nitric oxide
• Mechanisms
• Catalytic activity

Acknowledgements

The authors express their deep gratitude to Professor Rudi van Eldik for sharing knowledge and experience, stimulating and passionate introduction to the subject of the activation of small molecules and coordination chemistry of tetrapyrrole complexes. Faculty of Chemistry, Jagiellonian University, is a beneficiary of the European Regional Development Fund in the framework of the Polish Innovation Economy Operational Program (contract no. POIG.02.01.00-12-023/08). The research in the field of interaction of small molecules with the tetrapyrrole complexes of cobalt and manganese are carried out there with the financial support of the National Science Center in Poland (grant number DEC-2012/05/B/ST5/00389).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Science Center in Poland [grant number DEC-2012/05/B/ST5/00389].