Syntheses of crystal structures and in vitro cytotoxic activities of new copper(II) complexes of pyridine-2,6-dicarboxylate

Abstract

[Cu(pydc)(im)]_n (1), [Cu(pydc)(mim)₃]∙2H₂O (2), [Cu(pydc)(ampy)(H₂O)]∙H₂O (3), and [Cu(pydc)(phen)][Cu(Hpydc)₂] (4) (H₂pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, im = imidazole, mim = 2-methylimidazole, ampy = 2-amino-4-methylpyridine, and phen = 1,10-phenanthroline) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV–vis and IR spectra) and single crystal X-ray diffraction. Complexes 1, 2 and 3 were studied by thermogravimetric analysis from ambient temperature to 1100 K under nitrogen and thermal stabilities were investigated. The effects of complexes on proliferation of fibrosarcoma cells were investigated using the Quick Cell Proliferation Assay. The cell viability changes depend on the concentrations and type of complexes. According to cell proliferation/viability data, 4 was determined to be the most cytotoxic.

Keywords:

• 2,6-Pyridinedicarboxylate
• Crystal structure
• Cytotoxic activity
• Kinetic analysis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Dumlupınar University [project number 20012/22].