Neutral and cationic manganese(II)–diclofenac complexes: structure and biological evaluation

Abstract

The interaction of MnCl₂ with the non-steroidal anti-inflammatory drug sodium diclofenac in the presence of 2,2′-bipyridine and pyridine resulted in the formation of cationic and neutral mononuclear complexes [Mn(diclofenac)(2,2′-bipyridine)(H₂O)₂] (diclofenac) (1) and [Mn(diclofenac)₂(pyridine)₂(H₂O)₂] (2), respectively. The structure of 1 was characterized by X-ray crystallography. In a preliminary attempt to evaluate the biological properties and possible application, the interaction of the complexes with calf-thymus DNA and human or bovine serum albumins was monitored. Additionally, the ability of the compounds to scavenge radicals such as 1,1-diphenyl-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and hydroxyl radicals was evaluated; the complexes were more potent scavengers than free sodium diclofenac.

Keywords:

• Non-steroidal anti-inflammatory drugs
• Diclofenac
• Manganese(II) complexes
• Interaction with DNA
• Interaction with albumins
• Antioxidant activity

Acknowledgements

This research has been co-financed by European Social Fund (ESF) and Greek national funds (National Strategic Reference Framework (NSRF)): Archimides III. The project was also supported by EU COST Action CM1105.

Disclosure statement

No potential conflict of interest was reported by the authors.