Synthesis, characterization, and biological evaluation of silver(I) complexes of N′-(1-(pyrazin-2-yl)ethylidene)picolinohydrazide

Abstract

Three Ag⁺ complexes, [Ag(L)(NO₃)]_n (1), {[Ag(L)]·SbF₆·CH₂Cl₂}_n (2), and {[Ag(L)]·SO₃CF₃·CHCl₃}_n (3), based on a hydrazone ligand L have been obtained (L = N′-(1-(pyrazin-2-yl)ethylidene)picolinohydrazide) and characterized. Complexes 1–3 all show 1-D chain-like structures. Their antibacterial activity and interaction with serum albumin were investigated. These results indicate that these complexes show good antibacterial activities and binding affinity to serum albumin.

Keywords:

• Hydrazone
• Ag⁺ complexes
• antibacterial activity
• serum albumin interaction

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by the National Natural Science Foundation of China [grant number 21301108]; Natural Science Foundation of Shandong Province [grant number ZR2011HM065]; National College Students' Innovative and Entrepreneurial Training Plan of China [grant number 201410433034].