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Articles

Synthesis and anticancer property of one Ce(III) compound based on 5-(2-pyrazinyl)tetrazole-2-acetic acid

, , , , , , , & show all
Pages 1084-1092 | Received 17 Nov 2017, Accepted 18 Feb 2018, Published online: 26 Mar 2018
 

Abstract

Mononuclear [Ce(pztza)2(H2O)6](pztza)·H2O (1) (pztza = 5-(2-pyrazinyl)tetrazole-2-acetato) has been prepared and characterized by IR, elemental analysis and single-crystal X-ray diffraction. PEG-5000 (poly(ethyleneglycol-5000)) coated [Ce(pztza)2(H2O)6](pztza)·H2O nanoparticles (NPs) can disperse into distilled water. In vitro study on Hela cells shows that Hpztza is nontoxic while [Ce(pztza)2(H2O)6](pztza)·H2O NPs show high toxicity with half-maximal inhibitory concentration (IC50) of 17 μg/mL (1.93 × 10−5 M). In addition, such NPs can inhibit the migration of Hela cells effectively.

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