abstract
This study reports results of kinetic and mechanistic studies on the reactions of aquacobalamin (H2OCbl+) with oxo-derivatives of cysteine, that is, cysteinesulfinic and cysteic acids, hypotaurine and taurine. The reactions with cysteinesulfinic acid and hypotaurine result in formation of S-bound complexes, whereas cysteic acid and taurine are coordinated with aquacobalamin via amino-group. Reaction of taurine with H2OCbl+ produces a substantially more stable complex than with cysteic acid, whereas the affinity of cysteinesulfinic acid toward aquacobalamin is slightly higher than that of hypotaurine.
Disclosure statement
The authors declare no competing financial interests.