Effects of β-cyclodextrin-based Schiff-base Zn(II) complexes: synthesis, physicochemical characterization and their role in alleviating oxidative stress related disorder

Abstract

Two water-soluble zinc(II) complexes of β-cyclodextrin-based Schiff bases, viz., mono-6-deoxy-6-(4-(5-chloro-2-hydroxybenzylideneamino)-3,4-diaminotolune)-β-cyclodextrin (4a) and mono-6-deoxy-6-(4-(5-nitro-2-hydroxybenzylideneamino)-3,4-diaminotolune)-β-cyclodextrin (4b) have been synthesized and characterized by different analytical and spectroscopic techniques. These Zn(II) complexes were analyzed for their possible activity against oxidative stress through various biochemical methods. A detailed antioxidant profile directly associated with inflammation related carcinogenesis and several oxidative stress related disorders have been prepared with a motive to evaluate the free radical scavenging activities of the synthesized complexes. The immune cell cytotoxic properties (through MTT assay) and in vitro assay for the evaluation of their antioxidant activities against hydroxyl radical, nitric oxide, singlet oxygen, peroxynitrate and hydrogen peroxide, etc. were investigated. Obtained results clearly demonstrated the role of reactive oxygen species in various phases of oxidative stress related diseases; thus, the antioxidant and free radical scavenging capacities of the two synthesized Zn(II) complexes seem to stand in support of their beneficial effects and novelty for the immune system.

GRAPHICAL ABSTRACT

KEYWORDS:

• β-Cyclodextrin-based Schiff bases
• Zn(II) complexes
• antioxidant property
• oxidative stress

Acknowledgments

The authors are grateful to the Departmental Special Assistance Scheme under the University Grants Commission, New Delhi (SAP-DRS-III, No. 540/12/DRS/2013) for financial support and CDRI, Lucknow, India for elemental analysis and ¹H NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.