Synthesis, characterization and single crystal X-ray structures of oxidovanadium(V) complexes derived from N’-(2-hydroxy-3-methoxybenzylidene)-3,5-dimethoxybenzohydrazide with antibacterial activity

Abstract

A new oxidovanadium(V) complex, [VOL(OCH₃)(CH₃OH)] (1), was prepared from N’-(2-hydroxy-3-methoxybenzylidene)-3,5-dimethoxybenzohydrazide (H₂L). Reaction of 1 with ethyl maltol (HL') in methanol afforded the new oxidovanadium(V) complex, [VOLL'] (2). The complexes were characterized by IR, UV and ¹H NMR spectra. Structures of the complexes were further confirmed by single crystal X-ray determination. The V ions in the complexes are octahedral. The hydrazone ligands coordinate to V through the phenolate O, imino N, and enolate O. The ethyl maltolate ligand coordinates to V through the carbonyl and hydroxy oxygens. Both complexes show effective antibacterial activity against B. subtilis, S. aureus and P. aeruginosa. Thermogravimetric analysis was also performed.

Graphical Abstract

Keywords:

• Hydrazone
• Maltolate
• Oxidovanadium complex
• Crystal structure
• Antibacterial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by K.C. Wong Magna Fund in Ningbo University, Ningbo Natural Science Fund (Project No. 201701HJ-B01019) and State Key Laboratory Development Fund of Structural Chemistry and College of Science & Technology Ningbo University (Project No. YK19011).