Abstract
Four complexes having the formula [Zn(L)2] [L1 = (C18H20NS2–), N-(4-isopropyl-benzyl)-(benzyl)-dithiocarbamate], [L2 = (C10H12NS2–), N-(benzyl)-(ethyl)-dithiocarbamate], [L3 = (C19H22ONS2–), N-(4-isopropyl-benzyl)-(4-methoxy-benzyl)-dithiocarbamate], and [L4 = (C16H16NS2–), N-(benzyl)-(4-methyl-benzyl)-dithiocarbamate] have been contemplated, synthesized, and characterized by elemental analysis and IR, 1H, 13C NMR and UV–visible absorption spectra. All Zn(II) complexes have similar geometry and coordination number. Complex A2 (with ligand L2) crystallizes in triclinic system with space group P-1 having distorted square pyramidal geometry which was stabilized by weak C–H···π and C–H···S intramolecular interactions. The antibacterial, antibiofilm, and antitumor activities of the complexes have been screened and A2 and A3 showed their prominence. Interestingly, both A2 and A3 showed more killing potential against multi-drug resistant gram-positive isolates with MIC indices of 16 μg mL−1 and 16 μg mL−1, respectively, against both MRSA and MSSA, while the antitumor agent A3 showed its prominence with GI50 and LC50 41.15 and 133.73 µg mL−1, respectively.
Graphical Abstract
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Acknowledgements
We are thankful to Department of Chemistry, Institute of Sciences, Banaras Hindu University Varanasi for their Instrumentals facilities. We are also thankful to Prof. N. Singh, Department of Chemistry, Institute of Sciences, BHU Varanasi for his fruitful suggestions.
Disclosure statement
No potential conflict of interest was reported by the authors.