Advanced search
Publication Cover
Journal of Coordination Chemistry Volume 73, 2020 - Issue 8
Submit an article Journal homepage
99
Views
1
CrossRef citations to date
0
Altmetric
Articles

Synthesis and in vitro anticancer properties of a new La(III) coordination polymer

Xinyu HaoSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; ;Department of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Yan LiDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Xiaoyi LiuDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Jing’ao RenDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Conghao ShiDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Yuanhui LiuDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
,
Dengfeng ZouSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; Correspondence[email protected]
View further author information
,
Qiaoyun LiDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaView further author information
&
Gaowen YangDepartment of Chemistry and Material Engineering, Jiangsu Laboratory of Advanced Functional Material, Changshu Institute of Technology, Changshu, Jiangsu, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1223-1231 | Received 02 Nov 2019, Accepted 04 May 2020, Published online: 29 May 2020
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

{La(pytza)3(H2O)2·2H2O}n derived from 5-(4-pyridyl)tetrazole-2-acetic acid (Hpytza) has been synthesized by a solvothermal reaction of Hpytza and La(NO3)3·6H2O. In this compound, neighboring La3+ ions are doubly bridged by two pytza ligands in a μ1,3-COO syn-syn mode to form a binuclear unit, then adjacent binuclear units are doubly bridged to give a 1-D ladder-like chain. In vitro MTT assay on HeLa cells demonstrates that Hpytza is nontoxic while {La(pytza)3(H2O)2·2H2O}n has a low half inhibitory concentration (IC50) of 18.2 μg/mL. Furthermore, cell migration across a 2-D artificial gap indicates that this compound can effectively inhibit the migration of HeLa cells, suggesting its potential to interfere with the tumor metastasis in vivo.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors acknowledge financial support from the Natural Science Foundation of China (Grant No. 81460119).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,057.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.