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Journal of Coordination Chemistry Volume 73, 2020 - Issue 12
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Articles

Synthesis and anticancer property of an octanuclear Mn(III) compound based on pyrazole bifunctional ligand

Hongliang XuSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; ;Jiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaView further author information
,
Xinchen LiJiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaView further author information
,
Xujing ZhangSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; View further author information
,
Long PengSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; View further author information
,
Dengfeng ZouSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; Correspondence[email protected] [email protected]
View further author information
&
Jie YangJiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaCorrespondence[email protected] [email protected]
View further author information
Pages 1806-1816 | Received 28 Apr 2020, Accepted 22 Jun 2020, Published online: 13 Jul 2020
 
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Abstract

Herein, an octanuclear complex [Mn8(μ4-O)4(phpy)8(MeOH)4]·MeOH·H2O based on 5-(2-hydroxyphenyl)-3-pyrazole (HphpyH) has been successfully synthesized and characterized. The compound can self-assemble to form nanoparticles (NPs) by nanoprecipitation with PEG-5000. [Mn8(μ4-O)4(phpy)8(MeOH)4]·MeOH·H2O NPs have a low IC50 (half maximal inhibitory concentration) of only 44 μg/mL (2.3 μM) on HeLa cells. The results show that [Mn8(μ4-O)4(phpy)8(MeOH)4]·MeOH·H2O NPs are able to inhibit cell proliferation and migration in vitro.

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Additional information

Funding

The authors acknowledge financial support from the Natural Science Foundation of China (Grant No. 81460119), National Natural Science Foundation of Jiangsu Province (Grant No. BK2012210), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 10KJB430001) and the Opening Fund of Jiangsu Key.

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