Two coordination polymers: effect on the learning and memory impairment in epilepsy mice by regulating the mTOR signaling pathway

Abstract

Under similar hydrothermal conditions, via using the mixed-ligand method, two 3-D coordination polymers (CPs) [Zn(HIPA)(bmimb)]_n (1, bmimb = 1,4-bis(2-methyl-1H-imidazol-1-yl)benzene)) and [Cu₂(HIPA)₂ (bmib)₃]_n (2, bmib = 1,4-bis(1H-imidazol-1-yl)benzene) were fabricated based on the reaction of Zn(NO₃)₂·6H₂O or Cu(NO₃)₂·3H₂O with 5-(hydroxymethyl)isophthalic acid (H₃IPA) when N-donor co-ligands were present. The compounds were evaluated to improve the learning and memory impairment in epilepsy mice and the relationship between the mTOR signaling pathway and epilepsy is discussed. To determine the influence of 1 and 2 on epilepsy mice cognitive function, the Morris Water Maze Test was performed. The mTOR signaling pathway expression levels were then detected with western blot.

Graphical abstract

Keywords:

• Coordination polymers
• crystal structures
• epilepsy mice
• western blot

Disclosure statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Data availability statement

The data used to support the findings of this study are included within the article.