Abstract
Single-crystal XRD structure of binuclear tetranitrosyliron complex [Fe2(SR)2(NO)4] (1), R = 4-aminothiophenyl, has been described. The properties of 1 were studied by IR, Mössbauer, mass spectroscopy, and amperometry. Complex 1 was shown to form long-living nitrosyl intermediates in solution, which underlies its prolonged NO donor activity. In HeLa cells, 1 caused accumulation of NF-κB p50 but decreased the levels of NF-κB p65 in the nucleus, which led to inhibition of NF-κB dependent genes. The complex also induced increase of p53 protein levels and p21 gene activity, which led to the apoptotic cell death after G2/M cell cycle phase.
Graphical Abstract
![](/cms/asset/d0010995-a47e-4cc0-92c3-d05ae45f01e9/gcoo_a_1869222_uf0001_c.jpg)
Acknowledgements
The authors acknowledge the assistance of Dr. M.Z. Aldoshina, Y.V. Zubavichus and V.M. Martinenko. The work has been performed in accordance with the state task (State registration No. AAAA-A19-119071890015-6).
Disclosure statement
The authors declare no conflict of interest.