Syntheses, structures and antimicrobial properties of complexes based on 2-hydroxybenzaldehyde-4-aminoantipyrine Schiff base

Abstract

Two monomeric complexes, [NiL₂·3H₂O] (1) and [Nd₂L₃(NO₃)₃] (2), with a tridentate ONO-donor Schiff base ligand HL (HL = 2-hydroxybenzaldehyde-4-aminoantipyrine) have been synthesized. Single-crystal X-ray diffraction analysis indicates that the asymmetric unit of 1 contains one Ni(II) and two L⁻ ligands, while 2 consists of two Nd(III) ions, three L⁻ ligands, and three NO₃⁻ ions. Complexes 1 and 2 are both 0-D discrete monomers, and there are intermolecular π–π interactions in 1 and intramolecular π–π interactions in 2. The discrete [NiL₂·3H₂O] monomers are further connected through π–π interactions, resulting in a 3-D supramolecular structure. Powder XRD and TG-DSC were performed for 1 and 2. Antimicrobial experiments show that 1 displays significant antibacterial effect against Bacillary dysentery and Escherichia coli in comparison with that of Schiff base ligand.

Graphical Abstract

Keywords:

• 2-Hydroxybenzaldehyde
• 4-aminoantipyrine
• Schiff base
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Natural Science Foundation of Bengbu Medical University [Grant BYTM2019001, BYKY1701ZD], 512 Talent Cultivation Foundation [by51201201], Anhui Provence Natural Science Foundation [1908085MB45], and National University Student Innovation and Entrepreneurship Training Project [Grant 201710367031]