Synthesis, crystal structure and in vitro anticancer studies of bis(dibenzyldithiocarbamato)Zn(II)

Abstract

Bis(dibenzyldithiocarbamato)Zn(II), [Zn(dbzdtc)₂], was synthesized and characterized by spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. The compound is crystallized in a monoclinic space group P2₁/n with Zn(II) located on crystallographic twofold symmetry and coordinated to two molecules of dibenzyl dithiocarbamato anions to form a rare four-coordinate mononuclear Zn(II) complex in a see-saw geometry. The cytotoxicity of the complex was evaluated by MTT assay against breast cancer cells (MCF-7) and human embryonic kidney cells (HEK293). The results showed that the complex is active against MCF-7 breast cancer cells with IC₅₀ value of 6.41 and 4.423 μΜ against HEK293 cell line.

Graphical Abstract

Keywords:

• Dibenzyl dithiocarbamate
• Zn(II) complex
• crystal structure
• anticancer
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors acknowledge the award of research grant by National Research Foundation, South Africa.